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Recent Articles

Analysis of Referral Patterns to a Dento-Maxillofacial Radiologist from Dental Practitioners

Intra-oral radiography is ubiquitous in dentistry and practitioners are increasingly using extra-oral radiography in everyday practice. Practitioners may encounter findings on radiographs that they are unfamiliar with and are unsure of the clinical significance. This retrospective study aimed to ascertain the radiographic presentations which were more likely to prompt these clinicians to seek an opinion from a Dento-maxillofacial radiologist (DMFR) and the most common pathologies referred.

Non-Syndromic X Linked Intellectual Disability in Two Brothers with A Novel NLGN4X Gene Splicing Mutation (NC_018934.2: g. 1202C>A)

X-linked Intellectual Disability (XLID) is an extremely heterogeneous disorder for which many of the causative genes are still unknown. So far, more than one hundred genes of the X chromosome have been found to be altered in males manifesting intellectual disability (ID). NLGN4X is an XLID gene, which has been found, involved in autism and Asperger syndrome involving causative coding mutations.

Chromosomal Aberrations and HMGA2 Expression in Paroxysmal Nocturnal Hemoglobinuria

Somatic, inactivating PIGA mutations in haematopoietic stem cells, followed by an unknown autoimmune selection process in favor of the mutated clone, are thought to be important events in the pathogenesis of paroxysmal nocturnal hemoglobinuria (PNH). Recently, a second clonal event involving the HMGA2 gene was reported in some PNH cases, and over expression of this gene was postulated to promote proliferation of the mutated clone.

Switching Darunavir/Ritonavir to Darunavir/Cobicistat in Clinical Practice Experience with 150 patients through 48 weeks

Darunavir (DRV) boosted with ritonavir (RTV) is currently among the preferred antiretroviral agents. Cobicistat (COBI), a new cytochrome P450 inhibitor is replacing RTV as pharmacoenhancer. Coformulated DRV/COBI has been approved based on bioequivalence data; however, results on efficacy and safety in clinical practice are scarce. COBI inhibits creatinine tubular secretion, thus raising concerns about its renal safety.