Fisher exact test is one of most popularly used methods in modern data analyses. However, it is conservative because of discreteness. The mid-p method may reduce the conservativeness but it is defined by the factor 1/2, an extra term beyond data. This paper considers an adjustment defined by a data-based factor. The adjusted test is compared with other ten tests. Special attention is given to the comparison between the data-based factor and the factor 1/2. The standardized version of the adjusted test is asymptotically standard normal.
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Analyze the clinical profile of the spine with osteonecrosis in sickle cell disease. 610 patients were followed-up in this study between 2000 and 2017. 98 osteonecrosis were identified, 48 in the lumbar spine, 40 in the thoracic spine and 10 in both spine segments. We analyzed sex, age, genotype, and pain. Magnetic resonances and radiographs of the spine were performed.
Profile of Adult Lymphomas in Sub-Saharan Africa: A Monocentric Study of Histoimmunochemical Aspects
A total of 26 NHL patients (56.5%) and 20 LH cases (43.5%), aged 32-11 and 51-18 years respectively, were selected. Polyadenopathy was noted in 95% of cases of HL and 73.1% of cases of NHL (p=0.002). Patients were at Ann Arbor Stage II-IV in 80% of cases for the NHL and 70% of cases for LH (p: 0 ,317). Type B-Cell NHL entities were Diffuse Large Cell B Lymphoma (34.6%), Follicular Lymphoma (15.4%), Mantle Lymphoma (7.7%), Lymphocytic Lymphoma (7.7%), and Malt Lymphoma (3.8%). The NHL was type T-Cell in 30.8% of cases including 19.2% of anaplastic lymphoma. The HL were classic (80%) and nodular lymphocyte predominant Hodgkin lymphoma (20%). Specific treatment was performed in 82.6% of cases, 28.9% of which were immunochemotherapy. Remission was noted in 52.4% of NHL patients and 70.3% of those with HL.
During the Sars-CoV-2 pandemic in Italy, even though many people died due to virus-induced complications, there was a warm advice from the government against performing body autopsies, instigating their incineration. It was a reckless decision, leaving clinicians and scientists empty handed when it comes to studying infection-induced tissue changes and subsequent organ failures, making it more difficulties in finding a better clinical solution for combating the virus.